The settings.dat file is automatically created to handle some loading behaviour in Dehumaniser II on OS X.
On some systems, sometimes this file is not created, or cannot be accessed correctly due to user settings.
To fix this issue, navigate to this directory:
/Users/YOUR USERNAME/Library/Application Support/Krotos/Dehumaniser
Download the file from the link below.
Paste in the file in the path above, and reboot your DAW.
This should solve the issue